• To critically examine current research on how the blood-brain barrier (BBB) is altered during the formation of MS lesions, and on the mechanisms of actions of current disease modifying agents that affect the BBB
  • To identify potential new therapeutic targets for blocking the trafficking of immune cells into the nervous system in individuals with MS
  • To discuss the role of lymphocyte subsets in MS pathogenesis, as informed by pre-clinical studies and clinical trials of therapies that target B and/or T cells
  • To synthesize data on the detrimental versus beneficial effects of myeloid cell subsets in MS
  • To review recent studies on the contributions of astrocytes to MS disease activity and remission
  • To identify future directions for promoting remyelination in individuals with MS by modulating oligodendrocytes and their precursors
  • To provide mentorship to trainees and junior faculty interested in a career in MS research and/or clinical practice
  • To ensure that research findings are disseminated to various stakeholder groups, including MS care providers, researchers, news media outlets, social media and patient advocacy groups